Entebbe Cohort

The cohort was established among HIV-infected adults attending clinics in Entebbe. The MRC/UVRI in Entebbe, in collaboration with The AIDS Support Organisation (TASO), established and followed an open cohort study of HIV-infected participants from 1994 to 2009 to evaluate a variety of new interventions aiming to reduce HIV-associated morbidity and mortality.

Over time it has provided a well-characterised population for major treatment and prophylaxis research. This includes landmark work on the feasibility and effectiveness of daily cotrimoxazole prophylaxis in a well-established cohort of HIV-infected adults attending clinics in Entebbe, the COSTOP trial on safely discontinuing that prophylaxis, and antiretroviral therapy strategies such as the DART trial. Participants receive regular clinical follow-up alongside data and sample collection.

Findings from this work have informed HIV treatment and care guidelines in Uganda and internationally, and the linked longitudinal data and stored samples remain a valuable resource for continued research into HIV, co-infections and long-term outcomes.